Retrospective assessment of symptomatic and asymptomatic mumps virus infection: assessing attack rates and correlates of protectio
Completed
- Conditions
- 10047438mumpsparotitis epidemica
- Registration Number
- NL-OMON35231
- Lead Sponsor
- RIVM
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
Students of whom a stored serum samples prior to the beginning of the mumps outbreaks in September 2009 is available at the faculty.
>= 18 jaar
Exclusion Criteria
geen
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Symptomatic and asymptomatic mumps virus attack rates among fully vaccinated<br /><br>students through the analysis of specific (IgG) antibody responses prior to,<br /><br>and in response to mumps virus infection. </p><br>
- Secondary Outcome Measures
Name Time Method <p>• To estimate a serological correlate for immune protection against symptomatic<br /><br>mumps virus infection and asymptomatic mumps virus infection among fully<br /><br>vaccinated students by defining antibody titres necessary to protect against<br /><br>symptomatic mumps and asymptomatic mumps<br /><br>• To assess the seroresponse of mumps infection among incompletely vaccinated<br /><br>students and (if possible) the mumps attack rate in this group.</p><br>