Metformin usage leading to Vitamin B12 deficiency and complications arising from Vitamin B12 deficiency
Not Applicable
- Registration Number
- CTRI/2021/05/033755
- Lead Sponsor
- Dr Sudha Vidyasagar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Type 2 Diabetics as per ADA guidelines
Age 30-70 years
On Metformin
Exclusion Criteria
History of alcohol consumption
Pregnancy
Patients with liver failure, chronic hepatitis
Autoimmune Thyroid disease
Patients suffering from malignancies
Patients with Renal failure (Creatinine Clearance <30ml/min/stage 4 and above)
People suffering from bowel disorders such as â?? Atrophic gastritis,
Pernicious anemia, IBD, Chronic Pancreatitis, Whippleâ??s disease, Parasitic Infections,
Post bowel surgeries such as Gastrectomy, Terminal Ileal resection surgeries and Bariatric surgeries
Patients treated for Vitamin B12 deficiency with a course of IV Vitamin B12
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Occurrence of low Vitamin B12 levels in type 2 diabetics on metformin <br/ ><br>Occurrence of macrocytic anemia in type 2 diabetics on metformin <br/ ><br>occurrence of diabetic peripheral neuropathy in diabetics on metforminTimepoint: 1 YEAR 4 MONTHS
- Secondary Outcome Measures
Name Time Method Occurrence of macrocytic anemia in type 2 diabetics on metformin <br/ ><br>occurrence of diabetic peripheral neuropathy in diabetics on metforminTimepoint: 1 YEAR 4 MONTHS