Optical Coherence Tomography for the Etiological Diagnosis of Inflammatory Optic Neuritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Sensitivity of the OCT, expressed as a percentage, for the etiological diagnosis of optical neuritis
研究概览
简要总结
Optic neuritis (ON) can remain isolated or reveal a widespread and chronic disease of the central nervous system (CNS), a multiple sclerosis (MS) or, more rarely, a Devic's neuromyelitis optica (NMO) or a systemic disease.
The optical coherence tomography (OCT) is a retinal imaging technique to measure the thickness of the retina and its different layers with an accuracy of 4-6 µM.
Costello et al have shown that approximately 75% of 54 MS patients have developed within 3 to 6 months after a ON a loss of 10 to 40 µM in the thickness of the peripapillary retinal nerve fiber layer (RNFL).
The etiologic diagnosis of ON has been transformed in recent years. MS can now be diagnosed by McDonald's MRI criteria and NMO by the AQP4 antibodies (anti-aquaporin- 4) antibodies and the anti-MOG (myelin-oligodendrocyte glycoprotein) antibodies.
The diagnosis and prognosis value of the OCT in patients with ON is not well known
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •first onset of an optical neuritis lasting for less than 3 months
排除标准
- •Contra-indication to MRI
- •Patient opposed to participation in the study
- •Pregnant or lactating woman
- •Patient under a measure of legal protection
- •Absence of affiliation to social security or universal health coverage (CMU)
结局指标
主要结局
Sensitivity of the OCT, expressed as a percentage, for the etiological diagnosis of optical neuritis
时间窗: One year
次要结局
未报告次要终点