Effect of Garlic on Inflammatory Mediators
- Conditions
- Healthy
- Registration Number
- NCT00275405
- Lead Sponsor
- Albany Medical College
- Brief Summary
This research will investigate the effect of garlic oil extract when added to daily diet on inflammatory mediators and blood clotting activation.
- Detailed Description
To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 34
- 18 years of age and older
- Normal subjects with BMI <25, obese subjects with BMI >30
- Subjects who have consented to adhere to the diet, regular weekly visits, and blood draws.
- Subjects on any antioxidant medication.
- Patient on non-steroidal anti-inflammatory drug.
- On any agent with antioxidant properties.
- History of drug or alcohol abuse.
- Any life threatening disease.
- On any agent with significant antioxidant properties.
- Taking garlic extracts in the diet regularly.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method 1. To examine the pharmacokinetics of the garlic oil macerate.
- Secondary Outcome Measures
Name Time Method 2. To examine the effect of garlic oil macerate on inflammatory mechanisms at the cellular and molecular level.
Trial Locations
- Locations (1)
Albany Medical Center
🇺🇸Albany, New York, United States