The effect of sesame oil capsule on knee osteoarthritis

Phase 2

Recruiting

Conditions: Knee osteoarthritis.

Registration Number: IRCT20190406043175N6

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Primary symptomatic osteoarthritis in at least one knee confirmed by clinical or radiological criteria (American College of Rheumatology (ACR) criteria).
No adequate response to medical treatment (Meloxicam) after at least two weeks of administration before the start of the study.
A baseline visual analog scale (VAS) score higher than 30 at the beginning of the study.

Exclusion Criteria

The intra-articular injection of hyaluronic acid in the three months before the start of the study
The 4-week treatment with oral corticosteroids before the start of the study
Patients with a history of deep vein thrombosis
Active liver or renal disease and malignancies
Secondary osteoarthritis or suspected
Patients treated with hormonal drugs
Patients treated with anticoagulation drugs
Patients with a history of ischemic or hemorrhagic stroke

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: Western Ontario and McMasters Universities Osteoarthritis Index (Womac) questionnaire and Visual Analog Scale (VAS).;Joint stiffness. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC)questionnaire and Visual Analog Scale (VAS).;Physical performance. Timepoint: Early intervention, four weeks after the intervention, eight weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC)questionnaire and Visual Analog Scale (VAS).

Secondary Outcome Measures