The Accuracy of Amniotic Fluid Ferning in the Second Trimester in the Diagnosis of Preterm Prelabor Rupture of Membranes
- Conditions
- Preterm Premature Rupture of MembraneAmniotic Fluid Leakage
- Registration Number
- NCT04963465
- Lead Sponsor
- Albany Medical College
- Brief Summary
Although much investigation has been done on the use of ferning in the second and third trimesters, particularly with the development of rapid protein clinical assays, there appears to be lower ferning rates in clinical practice with traditional techniques compared to previous published research on the subject. Much of the older study designs are lacking in detail and lack a large enough sample sizes at each gestational age to appropriately interpret the significance of ferning results by gestational age. Additionally, a large premise for the current tests used to diagnose rupture of membranes is based on these older studies. Given this, we propose collecting amniotic fluid vaginally to evaluate for the presence of ferning in the second trimester to determine if there is a difference in ferning based on gestational age as well as the time interval after rupture of membranes in which ferning can observed on microscope examination.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 100
- 18 years or older
- English speaking
- singleton or multi fetal gestation
- between 15 and 24 weeks gestation
- undergoing elective pregnancy termination
- known rupture of membranes or anhydramnios
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ferning 20 minutes the presence of amniotic fluid ferning
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Albany Medical Center
🇺🇸Albany, New York, United States
Albany Medical Center🇺🇸Albany, New York, United StatesOBGYN Research DirectorContact518-262-4942Obgynresearch@amc.edu