NCT00146432已完成2 期
Prospective, Controlled Pilot Trial: Treatment of Patients in Severe Sepsis and Septic Shock With Immunoadsorption of LPS, IL-6, C5a
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 2
研究概览
简要总结
The purpose of this study is to determine whether immunoadsorption of LPS, Il-6 and C5a reduces systemic hyperinflammation, improves immune function and improves organ function in patients with severe sepsis and septic shock
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of severe sepsis or septic shock (ACCP/SCCM)
- •Presence of 4 SIRS criteria/indicators
- •Suspected or proven infection (refer also to: 1.)
- •Age 18-80
- •APACHE II score > 18
- •At least one acute organ dysfunction (renal/pulmonary/hemodynamics/cerebral)
排除标准
- •Suspected or proven pregnancy
- •Absolute contraindication for anticoagulation (active bleeding)
- •Absolute IgA-deficiency
- •History of anaphylactic reaction to egg-albumin
- •Participants in other clinical trials (<12 wks. prior to study inclusion)
研究者
研究点 (2)
Loading locations...
相似试验
暂停
2 期
Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive DisorderMajor Depressive DisorderNCT03787290Massachusetts General Hospital35
已完成
2 期
To Investigate the Safety, Pharmacodynamics and Effect on Allergic Reactivity of the Toll-like Receptor 7 (TLR7) Agonist GSK2245035 in Subjects With Respiratory AllergiesMild Asthma and Allergic RhinitisNCT01788813GlaxoSmithKline42
终止
4 期
Effect of Subcutaneous ACTEMRA on Inflamed Atherosclerotic Plaques in Patients With Rheumatoid ArthritisRheumatoid ArthritisNCT02659150Massachusetts General Hospital16
已完成
3 期
Safety and Immunological Efficacy of the Pentavalent Rotavirus Vaccine - Rota-V-Aid™ (Live Attenuated Oral, Freeze-dried) at Healthy Adults Aged 18 to 45 Years.Rotavirus InfectionsRotavirus VaccinesNCT05037435Limited Liability Company Pharm Aid40
Unknown
不适用
Assisted or Controlled Ventilation in Ards (Ascovent)ARDSVentilator-Induced Lung InjuryMechanical Ventilation ComplicationInflammatory ResponseNCT03245684University of Roma La Sapienza40