NCT02031913CompletedNot Applicable
Association Between Insulin Resistance and Hepatic Fibrosis in Combined Chronic Hepatitis B and Non-alcoholic Fatty Liver Disease
Seoul National University Boramae Hospital1 site in 1 country500 target enrollmentStarted: January 2013Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Insulin resistance and fibrosis indices
Study Overview
Brief Summary
Hepatic steatosis and insulin resistance are associated with severity of fibrosis in non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, clinical significance of steatosis and insulin resistance on fibrosis in chronic hepatitis B (CHB) is not well established. The aim was to investigate the relationship between insulin resistance, hepatic steatosis, and fibrosis in patients with CHB.
Detailed Description
acoustic radiation force impulse elastography
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 20 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Chronic hepatitis B patients
- •With evidences of hepatic steatosis on ultrasonography or pathology
Exclusion Criteria
- •significant alcohol consumption or other known liver diseases
Outcomes
Primary Outcomes
Insulin resistance and fibrosis indices
Time Frame: one year
Measurement for insulin resistance and fibrosis index for hepatic fibrosis assessment
Secondary Outcomes
No secondary outcomes reported
Investigators
Won Kim
M.D, PhD
Seoul National University Boramae Hospital
Study Sites (1)
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