Quantitative Ventilation Imaging With Dual Energy Computed Tomography
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Image quality on a qualitative 5 levels scale
研究概览
简要总结
Demonstrate the feasibility of dual energy computed tomography using Krypton as a gaseous contrast media in order to study the in vivo ventilation.
Two different clinical situations will be tested :
- Prediction of postoperative pulmonary function for oncologic patients
- Detection of Bronchiolitis Obliterans in lung transplant recipients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For oncologic patients :
- •Potentially operable lung tumor
- •With a recent (less than 1 month) V/Q scan
- •For lung transplant recipients :
- •Single of bilateral lung transplant
- •From 5 months onwards
- •With recent (less than 1 month) respiratory functional explorations
排除标准
- •Impossibility to follow simple orders or control one's respiration
- •Known Krypton hypersensitivity
- •History of malignant hyperthermia
- •Increased intracranial pressure
- •Pregnant Women
研究组 & 干预措施
oncologic patients
Prediction of postoperative pulmonary function.
Patients with an operable lung cancer: dual energy computed tomography with Krypton will be tested to estimate the postoperative FEV1
干预措施: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media (Radiation)
lung transplant recipients
Detection of BOS
6 months+ lung transplant recipients will be tested using dual energy computed tomography with Krypton, with acquisition in the end-inspiratory and end-expiratory phase, in search of regional air trapping.
干预措施: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media (Radiation)
结局指标
主要结局
Image quality on a qualitative 5 levels scale
时间窗: 1 day of DECT ventilation imaging
次要结局
- Image noise with measurement of signal to noise and contrast to noise ratios(1 day of DECT ventilation imaging)
- Total examination time(1 day of DECT ventilation imaging)
- Radiation dose(1 day of DECT ventilation imaging)