DECT Ventilation Imaging

Not Applicable

Terminated

• Conditions: With a Recent (Less Than 1 Month) VQ Scan; Potentially Operable Lung Tumor; From 5 Months Onwards; For Oncologic Patients; For Lung Transplant Recipients; Single of Bilateral Lung Transplant; With Recent (Less Than 1 Month) Respiratory Functional Explorations
• Interventions: Radiation: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media

• Registration Number: NCT02377518
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Demonstrate the feasibility of dual energy computed tomography using Krypton as a gaseous contrast media in order to study the in vivo ventilation.

Two different clinical situations will be tested :

* Prediction of postoperative pulmonary function for oncologic patients

* Detection of Bronchiolitis Obliterans in lung transplant recipients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-02-25
• Study First Submitted QC: 2015-03-02
• Study First Posted: 2015-03-03
• Study Start: 2015-06
• Primary Completion: 2016-01
• Study Completion: 2016-01
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-21
• Last Update Posted: 2018-03-23

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oncologic patients	Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media	Prediction of postoperative pulmonary function. Patients with an operable lung cancer: dual energy computed tomography with Krypton will be tested to estimate the postoperative FEV1
lung transplant recipients	Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media	Detection of BOS 6 months+ lung transplant recipients will be tested using dual energy computed tomography with Krypton, with acquisition in the end-inspiratory and end-expiratory phase, in search of regional air trapping.

Primary Outcome Measures

Name	Time	Method
Image quality on a qualitative 5 levels scale	1 day of DECT ventilation imaging

Secondary Outcome Measures

Name	Time	Method
Image noise with measurement of signal to noise and contrast to noise ratios	1 day of DECT ventilation imaging
Total examination time	1 day of DECT ventilation imaging
Radiation dose	1 day of DECT ventilation imaging

Trial Locations

Locations (1)

Service de Radiologie B - Nouvel Hôpital Civil - CHRU de Strasbourg; 🇫🇷 Strasbourg, France