Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis

Phase 4

Completed

• Conditions: Aggressive Periodontitis
• Interventions: Other: scaling and systemic moxifloxacin; Other: scaling and root planing

• Registration Number: NCT02125812
• Lead Sponsor: Facultad Nacional de Salud Publica

Brief Summary

The adjunctive use of systemically administered antibiotics has been shown to provide a better clinical outcome, particularly in terms of probing depth (PD) reduction and attachment-level gain than SRP in subjects with Aggressive Periodontitis.

The overall objective of this study is to evaluate the clinical and microbiological efficacy of moxifloxacin as an adjunct to scaling and root planing versus scaling and root planing over placebo in the treatment of aggressive periodontitis.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-08
• Primary Completion: 2014-03
• Study Completion: 2014-04
• Study First Submitted: 2014-04-25
• Study First Submitted QC: 2014-04-28
• Study First Posted: 2014-04-29
• Status Verified: 2014-05
• Last Update Submitted: 2014-05-29
• Last Update Posted: 2014-06-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• under 30 years old and systemically healthy, with at least 20 teeth present. Be willing to participate in the study which is corroborated by signing the informed consent form.

Commit to attend post-therapeutic controls and stop drinking alcohol during the time of ingestion of antibiotics.

Exclusion Criteria

• Subjects in whom are contraindicated or with hypersensitivity to quinolones - Subjects who have undergone periodontal, surgical or mechanical antibiotic therapy six months before the start of the study according to interrogation.

Women in pregnancy or lactation, corroborated with previous medical history and medical consultation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
scaling and systemic moxifloxacin	scaling and systemic moxifloxacin	scaling and root planing combined with systemic moxifloxacin
scaling and root planing	scaling and root planing	scaling and root planing

Primary Outcome Measures

Name	Time	Method
probing depth	six months

Secondary Outcome Measures

Name	Time	Method
clinical attachment level and probing depth	6 moths

Trial Locations

Locations (1)

Faculty of Dentistry; 🇨🇴 Departamento de Antioquia, Medellin, Colombia