Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis: Double-blind Controlled Clinical Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- probing depth
研究概览
简要总结
The adjunctive use of systemically administered antibiotics has been shown to provide a better clinical outcome, particularly in terms of probing depth (PD) reduction and attachment-level gain than SRP in subjects with Aggressive Periodontitis.
The overall objective of this study is to evaluate the clinical and microbiological efficacy of moxifloxacin as an adjunct to scaling and root planing versus scaling and root planing over placebo in the treatment of aggressive periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •under 30 years old and systemically healthy, with at least 20 teeth present. Be willing to participate in the study which is corroborated by signing the informed consent form.
- •Commit to attend post-therapeutic controls and stop drinking alcohol during the time of ingestion of antibiotics.
排除标准
- •Subjects in whom are contraindicated or with hypersensitivity to quinolones - Subjects who have undergone periodontal, surgical or mechanical antibiotic therapy six months before the start of the study according to interrogation.
- •Women in pregnancy or lactation, corroborated with previous medical history and medical consultation.
研究组 & 干预措施
scaling and root planing
scaling and root planing
干预措施: scaling and root planing (Other)
scaling and systemic moxifloxacin
scaling and root planing combined with systemic moxifloxacin
干预措施: scaling and systemic moxifloxacin (Other)
结局指标
主要结局
probing depth
时间窗: six months
次要结局
- clinical attachment level and probing depth(6 moths)
研究者
Carlos Martin Ardila Medina
Titular Professor
Universidad de Antioquia