JPRN-jRCT1031210331尚未招募2 期
Efficacy of Duloxetine for Chronic postsurgical Pain after Total Hip ArthroplastyA randomized controlled trial
ishi Masanori0 个研究点目标入组 100 人开始时间: 2021年9月22日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1) Patients who have osteoarthritis of hip
- •2) Aged more than 20 years
- •3) Persons who have not taken duloxetine or two weeks since last dose
- •4) Written informed consent
排除标准
- •1) Persons with a history of hypersensitivity to the duloxetine
- •2) Persons administering monoamine oxidase (MAO) inhibitors
- •3) Persons administering medicines that have a strong inhibitory effect on CYP1A2
- •4) Persons with severe liver damage (ALAT or ASAT>100IU/L) , history of liver cirrhosis, or liver transplantation
- •5) Persons with renal damage (eGFR<30mL/min), renal transplantation, or dialysis therapy
- •6) Depression (HAM-D score > 7)
- •7) Persons with alcohol or other dependence within 5 years
- •8) Persons with severe cardiovascular disease
- •9) Hyponatremia (<135 nmol/L)
- •10) Persons with uncontrolled hypertension
- •11) Patients with glaucoma, thyroid disease, or epilepsy
- •12) Persons who are or may be pregnant
- •13) Persons with a history of hypersensitivity to the Non-Steroidal Anti-Inflammatory Drugs or aspirin-induced asthma.
- •14) Persons who are judged by the research-responsible (sharing) doctor to be inappropriate for participation in this research
研究者
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