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Clinical Trials/NCT05727865
NCT05727865
Completed
Not Applicable

Online Cognitive Behavioral Therapy for Rehabilitation After Cardiac Surgery

Karolinska Institutet1 site in 1 country30 target enrollmentFebruary 17, 2023
ConditionsCardiac Surgery

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Cardiac Surgery
Sponsor
Karolinska Institutet
Enrollment
30
Locations
1
Primary Endpoint
Percentage of enrolled participants who complete the treatment
Status
Completed
Last Updated
last year

Overview

Brief Summary

The purpose of the present pilot study is to evaluate the feasibility and potential efficacy of a brief, internet-delivered CBT protocol provided early following cardiac surgery.

Detailed Description

Cardiac surgery is a major surgical procedure used to treat for example coronary artery disease (CAD). The intervention increases survival rates and reduces cardiac symptom burden in cardiac patients. However, cardiac surgery is associated with elevated symptoms of psychological distress, which are related to several negative outcomes, such as poorer health-related quality of life (QoL) and response to treatment. There is a clear need to develop a brief psychological intervention that can be provided early in the clinical course after cardiac surgery to reduce psychological distress. The purpose of this pilot study is to evaluate the feasibility and potential efficacy of a brief, exposure-based internet-delivered CBT protocol provided early after cardiac surgery. This is an uncontrolled pilot study with a pretest-posttest design. The study will include 30 participants. Assessments will be conducted pre-treatment, post-treatment, one- and six months after treatment. The one-month follow-up is the primary endpoint. The treatment lasts for five weeks and will be provided as an early intervention following cardiac surgery ≥ eight weeks to nine months before assessment. It will include psychoeducation, behavioral activation to address post-operative fatigue and depression, interoceptive exposure to reduce fear of cardiac-related symptoms and in-vivo exposure to reduce avoided situations, and activities to enhance physical activity and wellbeing.

Registry
clinicaltrials.gov
Start Date
February 17, 2023
End Date
December 22, 2023
Last Updated
last year
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Josefin Särnholm

PhD, Lic. Psychologist

Karolinska Institutet

Eligibility Criteria

Inclusion Criteria

  • (A) Cardiac surgery (i.e., CABG, heart valve repair/replacement, aortic repair or combined CABG and valve repair/replacement) ≥ eight weeks to nine months before assessment
  • (B) Age 18 years and above;
  • (C) Endorses postoperative psychological distress and/or interference with daily life
  • (D) On medical treatment for the cardiac condition according to clinical guidelines;
  • (E) Ability to read and write in Swedish

Exclusion Criteria

  • (F) Prior cardiac surgery with ventricular assist device or heart transplant;
  • (G) Hospitalized or living in a care facility;
  • (H) Any medical restriction to be physical active;
  • (I) Severe medical illness i.e., terminal cancer ;
  • (J) Severe psychiatric disorder or risk of suicide;
  • (K) Alcohol dependency;
  • (L) Ongoing psychological treatment.

Outcomes

Primary Outcomes

Percentage of enrolled participants who complete the treatment

Time Frame: Baseline to 5 weeks

Feasibility of the intervention components will be assessed by \>60% assessed as treatment completers. Descriptive analysis will also provide number of messages and therapist time.

Adverse events

Time Frame: Baseline to 5 weeks

Potential adverse reactions to the treatment. Participants will be asked to report and rate the short- and long term discomfort of the adverse event on a scale from 0 ('did not affect me at all') and 3 ('affected me very negatively').

Acceptability: Client satisfaction Questionnaire

Time Frame: Baseline to 5 weeks.

Treatment satisfaction, score ranging from 0 to 32, with a higher score indication more satisfaction with the treatment. Treatment satisfaction, score ranging from 0 to 32, with a higher score indication more satisfaction with the treatment. Treatment satisfaction, score ranging from 0 to 32, with a higher score indication more satisfaction with the treatment.

12-Item Short-Form Health Survey

Time Frame: Baseline to 2 months

General quality of life, with a score ranging from 0 to 100. A higher score indicating a better quality of life General quality of life, with a score ranging from 0 to 100. A higher score indicating a better quality of life

Secondary Outcomes

  • Generalized Anxiety Disorder 7-item(Baseline to 7 months)
  • 12-Item Short-Form Health Survey(Baseline to 7 months)
  • Cardiac anxiety questionnaire(Baseline to 7 months)
  • Brief Pain Inventory Short Form(Baseline to 7 months)
  • Symptom checklist Severity and Frequency Scale (SCL, adapted to coronary artery disease)(Baseline to 7 months)
  • Patient Health Questionnaire-9(Baseline to 7 months)
  • University of Toronto Atrial fibrillation Severity Scale (AFSS)(Baseline to 7 months)
  • Multidimensional fatigue inventory(Baseline to 7 months)
  • The Godin Leisure-time Exercise and International Physical Activity Questionnaire 1 item on inactivity(Baseline to 7 months)

Study Sites (1)

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