Renin Angiotensin SyStem blockade: diabetes nephropathy
Not Applicable
Completed
- Conditions
- Diabetic Nephropathy (DN)Nutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN65752530
- Lead Sponsor
- Canadian Institutes of Health Research (CIHR) (Canada)
- Brief Summary
2011 Results article in https://doi.org/10.2337/dc11-0476 (added 27/10/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 223
Inclusion Criteria
1. Patients with type one diabetes
2. Normal Glomerular Filtration Rate (GFR) and Blood Pressure (BP)
3. Normoalbuminuria
4. Either sex, 18 to 64 years of age
Exclusion Criteria
1. Type one Diabetes Mellitus longer then 20 years
2. BP more than 135/85 mmHg
3. GFR less than 90 ml/min
4. Microalbuminuria
5. Soiltary kidney
6. Other chronic disease
7. Pregnancy or planning pregnancy within two years of randomisation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome is to determine, in Type one diabetes without clinical evidence of diabetic nephropathy, if inhibition of the renin-angiotensin system activity can prevent or retard the rate of development of the histologic lesions associated with diabetic nephropathy.
- Secondary Outcome Measures
Name Time Method <br> 1. Retinopathy<br> 2. Microalbuminuria<br> 3. Blood pressure<br> 4. GFR<br> 5. Creatinine<br>