ISRCTN94728379
Active, not recruiting
未知
Characterising disease mechanisms in patients with coronary microvascular disease
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Coronary microvascular disease
- Sponsor
- King's College London
- Enrollment
- 74
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. All adult patients attending for diagnostic coronary angiography for stable angina at St. Thomas’ Hospital who are found to have unobstructed coronary arteries (epicardial coronary artery stenosis \< 30% and/or pressure wire negative stenosis).
- •2\. Tertiary referrals for invasive microvascular assessment of patients with angina and established unobstructed coronary arteries.
Exclusion Criteria
- •Current exclusion criteria as of 22/05/2023:
- •1\. Patients who are unable or unwilling to consent
- •2\. Contraindications to adenosine
- •3\. Contraindications to amlodipine and/or ranolazine
- •4\. Patients who are already taking the study medications for clinical reasons and are unable to stop them
- •5\. Presence of more than moderate valve disease
- •6\. Previous percutaneous coronary intervention or bypass surgery
- •7\. Known structural heart disease (e.g. cardiomyopathy or congenital heart disease)
- •8\. Pregnant or breastfeeding females
- •9\. Patients who are unable to exercise on a treadmill or those who can exercise for \>540 seconds in the absence of any revealed cardiac symptoms on baseline exercise test
Outcomes
Primary Outcomes
Not specified
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