Limb Ischemic Preconditioning for Prevention of Contrast Media Induced Nephropathy in Diabetic Kidney Patient
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Ramathibodi Hospital
- Enrollment
- 200
- Locations
- 2
- Primary Endpoint
- kidney injury before and after coronary angiogram.
Study Overview
Brief Summary
Contrast media induced nephropathy (CIN) is considered to be a serious complication in patient who underwent coronary angiogram (CAG). The pathogenesis of CIN does not well understood. The probable one is the contrast media makes the afferent vessel in glomeruli constrict and results in renal shut down. Limb ischemic preconditioning, a procedure that makes muscles become ischemic and adapt themselves to produce some cytokines for signaling the vessel more dilated. After the reperfusion, these cytokines are getting back to systemic circulation and effect the afferent vessel in glomeruli to become more dilated and prevent CIN.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Prevention
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Documented diabetic kidney disease
- •Elective coronary angiogram
- •Glomerular filtration rate < 60 ml/min by Cockroft-Gault or Modification of Diet in Renal Disease or CKD-EPI
Exclusion Criteria
- •Refuse or reject to inform consented
- •Hemodynamic compromise (Heart failure, need for intraaortic balloon pump)
- •Expose to drug or chemical substances potentially to be a nephrotoxic agent with in 1 mo (Not include preexisting Angiotensin converting enzyme inhibitor or Angiotensin receptor blocker with stable serum creatinine)
- •Documented or suspected of peripheral arterial disease, upper or lower limb
- •Bleeding diathesis
- •Contraindicated for coronary angiogram
- •currently on renal replacement therapy
Outcomes
Primary Outcomes
kidney injury before and after coronary angiogram.
Time Frame: 1 year
Secondary Outcomes
No secondary outcomes reported
Investigators
Sirapat Poonvutikul
Cardiology unit
Ramathibodi Hospital