Limb Ischemic Preconditioning for Prevention of Contrast Media Induced Nephropathy in Diabetic Kidney Patient

Not Applicable

• Conditions: Serum Cystatin C Before and After Coronary Angiogram; Serum Creatinine Before and After Coronary Angiogram
• Interventions: Procedure: limb ischemic preconditioning

• Registration Number: NCT01763034
• Lead Sponsor: Ramathibodi Hospital

Brief Summary

Contrast media induced nephropathy (CIN) is considered to be a serious complication in patient who underwent coronary angiogram (CAG). The pathogenesis of CIN does not well understood. The probable one is the contrast media makes the afferent vessel in glomeruli constrict and results in renal shut down. Limb ischemic preconditioning, a procedure that makes muscles become ischemic and adapt themselves to produce some cytokines for signaling the vessel more dilated. After the reperfusion, these cytokines are getting back to systemic circulation and effect the afferent vessel in glomeruli to become more dilated and prevent CIN.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-12-23
• Study First Submitted QC: 2013-01-06
• Study First Posted: 2013-01-08
• Study Start: 2013-02
• Status Verified: 2013-04
• Last Update Submitted: 2013-04-22
• Last Update Posted: 2013-04-23
• Primary Completion: 2013-12
• Study Completion: 2014-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Documented diabetic kidney disease
• Elective coronary angiogram
• Glomerular filtration rate < 60 ml/min by Cockroft-Gault or Modification of Diet in Renal Disease or CKD-EPI

Exclusion Criteria

• Refuse or reject to inform consented
• Hemodynamic compromise (Heart failure, need for intraaortic balloon pump)
• Expose to drug or chemical substances potentially to be a nephrotoxic agent with in 1 mo (Not include preexisting Angiotensin converting enzyme inhibitor or Angiotensin receptor blocker with stable serum creatinine)
• Documented or suspected of peripheral arterial disease, upper or lower limb
• Bleeding diathesis
• Contraindicated for coronary angiogram
• currently on renal replacement therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
limb ischemia	limb ischemic preconditioning	-

Primary Outcome Measures

Name	Time	Method
kidney injury before and after coronary angiogram.	1 year

Trial Locations

Locations (1)

Ramathibodi Hospital; 🇹🇭 Bangkok, Thailand