Limb Ischemic Preconditioning for Prevention of Contrast Media Induced Nephropathy in Diabetic Kidney Patient
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- kidney injury before and after coronary angiogram.
研究概览
简要总结
Contrast media induced nephropathy (CIN) is considered to be a serious complication in patient who underwent coronary angiogram (CAG). The pathogenesis of CIN does not well understood. The probable one is the contrast media makes the afferent vessel in glomeruli constrict and results in renal shut down. Limb ischemic preconditioning, a procedure that makes muscles become ischemic and adapt themselves to produce some cytokines for signaling the vessel more dilated. After the reperfusion, these cytokines are getting back to systemic circulation and effect the afferent vessel in glomeruli to become more dilated and prevent CIN.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Documented diabetic kidney disease
- •Elective coronary angiogram
- •Glomerular filtration rate < 60 ml/min by Cockroft-Gault or Modification of Diet in Renal Disease or CKD-EPI
排除标准
- •Refuse or reject to inform consented
- •Hemodynamic compromise (Heart failure, need for intraaortic balloon pump)
- •Expose to drug or chemical substances potentially to be a nephrotoxic agent with in 1 mo (Not include preexisting Angiotensin converting enzyme inhibitor or Angiotensin receptor blocker with stable serum creatinine)
- •Documented or suspected of peripheral arterial disease, upper or lower limb
- •Bleeding diathesis
- •Contraindicated for coronary angiogram
- •currently on renal replacement therapy
结局指标
主要结局
kidney injury before and after coronary angiogram.
时间窗: 1 year
次要结局
未报告次要终点
研究者
Sirapat Poonvutikul
Cardiology unit
Ramathibodi Hospital