Comparison of 250 ml Versus 500 ml of Fluid Challenge on Oxygen Consumption in Critical Care Patients: an Open Label Multicentre Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- VO2 after fluid challenge
研究概览
简要总结
The objective of fluid challenge is to increase oxygen delivery (DO2) in order to improve/restore tissue oxygen consumption (VO2). However the fluid challenge volume to administer stills in debate, some studies recommend to administer 250 mL. Previous studies suggested that 500 mL of fluid challenge administration may improve cardiac output and oxygen delivery. The relation between the amount of fluid expansion and oxygen delivery and oxygen consumption was not yet been studied in a randomized study in critical care patients. This is the purpose of this study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient for whom the physician in charge decided to infuse fluid challenge because of signs of acute circulatory failure (systolic arterial blood pressure < 90mmHg, and/or mean arterial blood pressure< 65 mmHg, and/or the need of vasopressive amine infusion, and/or skin mottling, and/or diuresis <0.5 mL/kg/h for more than 2 hours, and/or arterial lactate level>2mmol/L.
- •Echogenic patient
- •Patient with a Stroke Volume (SV) variation with passive leg raising (PLR) more than 10%.
- •Patient with regular sinus rhythm.
- •Patient who received protocol information.
排除标准
- •Age Under 18-year-old.
- •Pregnancy.
研究组 & 干预措施
250 mL of fluid challenge
干预措施: Fluid challenge (Other)
500 mL of fluid challenge
干预措施: Fluid challenge (Other)
结局指标
主要结局
VO2 after fluid challenge
时间窗: 60 minutes after fluid challenge.
Tissue oxygen consumption (VO2) after fluid challenge
VO2 after fluid challenge
时间窗: 30 minutes after fluid challenge.
Tissue oxygen consumption (VO2) after fluid challenge
次要结局
- Systolic heart function (LVEF)(Immediately, 30 and 60 minutes after fluid challenge.)
- Respiratory variation of stroke volume(Immediately, 30 and 60 minutes after fluid challenge.)
- Respiratory variation of the pulse pressure(30 and 60 minutes after fluid challenge.)
- Change of arterial lactate concentration from baseline(60 minutes after fluid challenge.)
- PaO2/FiO2(Immediately, 30 and 60 minutes after fluid challenge.)
- Stroke volume variation with passive leg raising (PLV)(30 and 60 minutes after fluid challenge.)
- Diastolic heart function(Immediately, 30 and 60 minutes after fluid challenge.)
- Change of arterial lactate concentration from baseline(30 minutes after fluid challenge.)