Phase Angle as a Marker of Muscle Damage, Muscle Fatigue and Inflammation, After Eccentric Exercise

Not Applicable

Recruiting

• Conditions: Phase Angle

• Registration Number: NCT05583500
• Lead Sponsor: Universidad Francisco de Vitoria

Brief Summary

The purpose of this study will be to assess the effectiveness of bioimpedance device (BIA) as a safe, rapid, and non-invasive method of analyzing muscle damage induced by high intensity induced eccentric exercise as an alternative measurement tool against traditional assessment methods.

A sample of 28 sedentary subjects will be recruited, all participants will perform an eccentric exercise protocol.

Measurements will be done before performing the exercise protocol, immediately after finishing the protocol, 3h after the end of the exercise protocol, 24h after the end of the exercise protocol and 48h after the end of the exercise protocol.

The variables analyzed in all subjects will be phase angle, creatinkinase, jumping strength, VAS scale, white blood count cell, quadriceps muscle thickness, Borg scale and anxiety and depression questionnaires.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-09
• Study Start: 2022-09-19
• Study First Submitted: 2022-09-29
• Study First Submitted QC: 2022-10-13
• Last Update Submitted: 2022-10-13
• Study First Posted: 2022-10-17
• Last Update Posted: 2022-10-17
• Primary Completion: 2022-12-19
• Study Completion: 2023-01-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Healthy subjets
• Sedentary subjects

Exclusion Criteria

• Trained subjects
• Subjects with musculoskeletal pathology
• Previous Surgeries in the last 6 months
• Subjects under pharmacological treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Phase angle	change from baseline to 72 hours	The phase angle, which is measured via bioelectrical impedance analysis (BIA), InBody 770 ,is a clinically important bioimpedance parameter used for nutritional assessment and evaluating the risk of various diseases. The phase angle was calculated automatically by the BIA device from these two components according to the following formula: phase angle (°) = (reactance/resistance) × (180°/π).

Secondary Outcome Measures

Name	Time	Method
Creatinkinase (CK concentration)	change from baseline to 72 hours	CK concentration will be measure in mg/dl with a portal analyzer (SpotchemTM EZ SP-4430), using test strips.
cellular inflammatory markers	change from baseline to 72 hours	Cellular inflammatory markers will be measured with hematology analyzer (Sysmex KX-21N Automed) in 10\^9/L and % White blood count, lymphocytes, neutrophils, monocytes, eosinophils, basophils will be analyzed
Pain: VAS	change from baseline to 72 hours	Visual Analogic Scale. Pain will be measured with a visual analog scale from 0 to 10. 0 points is no pain.
Quadriceps thickness	change from baseline to 72 hours	Quadriceps muscle thickness will be measures in mm. by an ultrasound device
Leg power	change from baseline to 72 hours	Leg power will be assessed using vertical jump test, with Chronojump platform (CHRONOJUMP Boscosystem)

Trial Locations

Locations (1)

Universidad Francisco de Vitoria; 🇪🇸 Pozuelo De Alarcón, Madrid, Spain