Myocarditis and the Role of Advanced Magnetic Resonance Imaging
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocarditis
- Sponsor
- Heart Center Leipzig - University Hospital
- Enrollment
- 129
- Locations
- 1
- Primary Endpoint
- Accuracy, sensitivity and specificity of magnetic resonance imaging sequences
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is the assess the diagnostic performance of magnetic resonance imaging in patients with suspected myocarditis by applying different imaging sequences at different MR scanners
Detailed Description
In patients with clinical suspicion of myocarditis biventricular endomyocardial biopsy is performed for definite diagnosis. In addition, patients undergo magnetic resonance imaging at 1.5 Tesla and 3.0 Tesla within 24 hours. The imaging protocol of both scan include assessment of myocardial edema respectively edema ratio; myocardial hyperemia respectively global relative enhancement (gRE); myocardial fibrosis/necrosis respectively myocardial LE and T1 and T2 mapping sentences. Diagnostic performance of different imaging protocols as compared to the findings of endomyocardial biopsies is calculated. The protocol also includes a follow-up MR can at 3 months.
Investigators
Philipp Lurz
Clinical Investigator, Professor, Managing Senior Physician
Heart Center Leipzig - University Hospital
Eligibility Criteria
Inclusion Criteria
- •Symptoms such as:
- •Dyspnea or Orthopnea or
- •Palpitations or
- •Exercise intolerance or
- •Evidence of myocardial involvement:
- •ventricular dysfunction on echocardiography or
- •new or persistent ECG changes
- •elevated Troponin T History of viral infection
Exclusion Criteria
- •Contraindication for magnetic resonance imaging
- •Impaired renal function: glomerular filtration rate ≤ 30 ml/min/m2
- •Patients presenting with pregnancy
- •Patients without informed consent
- •Participation in another trial.
Outcomes
Primary Outcomes
Accuracy, sensitivity and specificity of magnetic resonance imaging sequences
Time Frame: baseline
The diagnostic accuracy of individual and a combination of MR imaging sequences (late enhancement images, assessment of global edema, relative enhancement and T1 and T2 mapping sequences) will be determined by comparison to endomyocardial biopsies, which serve as diagnostic gold-standard
Secondary Outcomes
- Diagnostic performance of biventricular endomyocardial biopsies(baseline)