The Role of CircDENND4C in Epithelial Ovarian Cancer
- Conditions
- Ovarian Cancer
- Registration Number
- NCT06617585
- Lead Sponsor
- Assiut University
- Brief Summary
circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs \[8\], are involved in the regulation of various biological functions. They act by sponging off certain microRNAs (miRNAs) and play a role in the pathogenesis of many diseases, including cancers \[9-11\]. In addition, circRNAs are not com- monly degraded by RNA enzymes present in body flu- ids \[8\], and most of them possess expression specificity at the tissue, cell, and developmental stage level \[12,13\]. Thus, they can be ideal clinica
- Detailed Description
epithelial OC (EOC), the most common form of OC, accounts for 90% of all OC cases \[2\]. EOC has the highest mortality among all gynecologic tumors and poses a serious threat to women's life \[3\].herefore, early clinical diagnosis is crucial. Commonly used laboratory indicators for OC diagnosis
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Female
- Target Recruitment
- 30
- patients at South Egypt Cancer institute and Recently diagnosed ovarian cancer patients 2. Patients not went to surgery.
- . Patients receive any anti-cancer therapy. 2. Patients diagnosed with other concomitante cancer or chronic disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method role of circDENND4c in the diagnosis of ovarian cancer baseline by quality real time PCR we use the circDENND4c as a tumour marker for ovarian cancer
- Secondary Outcome Measures
Name Time Method