The Role of CircDENND4C in Epithelial Ovarian Cancer
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 主要终点
- role of circDENND4c in the diagnosis of ovarian cancer
研究概览
简要总结
circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs [8], are involved in the regulation of various biological functions. They act by sponging off certain microRNAs (miRNAs) and play a role in the pathogenesis of many diseases, including cancers [9-11]. In addition, circRNAs are not com- monly degraded by RNA enzymes present in body flu- ids [8], and most of them possess expression specificity at the tissue, cell, and developmental stage level [12,13]. Thus, they can be ideal clinica
详细描述
epithelial OC (EOC), the most common form of OC, accounts for 90% of all OC cases [2]. EOC has the highest mortality among all gynecologic tumors and poses a serious threat to women's life [3].herefore, early clinical diagnosis is crucial. Commonly used laboratory indicators for OC diagnosis
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •patients at South Egypt Cancer institute and Recently diagnosed ovarian cancer patients
- •Patients not went to surgery.
排除标准
- •. Patients receive any anti-cancer therapy.
- •Patients diagnosed with other concomitante cancer or chronic disease
结局指标
主要结局
role of circDENND4c in the diagnosis of ovarian cancer
时间窗: baseline
by quality real time PCR we use the circDENND4c as a tumour marker for ovarian cancer
次要结局
未报告次要终点
研究者
Marwa Mamdouh Mohamed Abdellah
doctor
Assiut University