The Influence of Exercise and Hydration to the Pharmacological Response to Inhaled Terbutalin and Salbutamol in Men
Phase 4
Withdrawn
- Conditions
- Healthy
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT05749523
- Lead Sponsor
- Vibeke Backer
- Brief Summary
To investigate the effects of dehydration and exercise for the urine secretion of beta2-agonists.
- Detailed Description
No studies have examined the influence of factors such as exercise and dehydration on the pharmacokinetic profile of asthmatic drugs (beta2-agonists). Exercise may modify the metabolism and excretion of drugs, and sweat loss during exercise can result in dehydration, both affecting the urine concentration of the drug.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria
- men
- aerobic capacity more than 50ml / min / kg
- more than 5h training pr week
Exclusion Criteria
- smokers
- allergy for the medicine
- chronic diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Exercise Exercise Exercise vs. non-exercise
- Primary Outcome Measures
Name Time Method Urine concentration of salbutamol and terbutalin 7 days Urine concentration of salbutamol and terbutalin
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Respiratory Medicine, L, Bispebjerg Hospital,
🇩🇰Copenhagen, NV, Denmark