Hepatic Vein-sparing Hepatectomy for Colorectal Liver Metastases at the Caval Confluence: Validation on Intention-to-treat Analysis of a IOUS-guided Approach
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- the safety of HV-sparing surgery in terms of operative mortality and morbidity
研究概览
简要总结
Major hepatectomies are generally selected for tumors involving the hepatic vein (HV) at the caval confluence (CC). As alternative, HV reconstruction has been proposed. The present study aimed to evaluate the feasibility and safety of a HV-sparing policy guided by intraoperative ultrasonography (IOUS) in a cohort of patients having at least one colorectal liver metastasis (CLM) in contact with a HV at CC. HV section can be avoided in the large majority of cases thanking to CLMs detachment or to HV partial resection or reconstruction: this policy seems feasible, safe, reduces the need of major hepatectomies, and oncologically provides an adequate local control.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 28 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of at least one CLM in contact with HV at caval confluence and HV patency at preoperative imaging
- •at least 6 months of follow-up after surgery
排除标准
- •suspected or ascertained thrombosis or full tumoral involvement of HV at preoperative imaging
- •portal pedicle infiltration and/or thrombosis
- •unresectability at laparotomy for any extra-hepatic or intrahepatic reason not related to tumor-vessel relations
结局指标
主要结局
the safety of HV-sparing surgery in terms of operative mortality and morbidity
时间窗: within 30-90 days after surgery
次要结局
未报告次要终点
研究者
Prof. Guido Torzilli
Guido Torzilli, MD, PhD, FACS, Professor of Surgery, Director Department of Hepatobiliary & General Surgery, University of Milan, Humanitas Research Hospital, Rozzano, Milan
University of Milan