Nuclear Genetic and Mitochondrial Influences in Glaucoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Primary Open Angle Glaucoma
- Sponsor
- Wills Eye
- Enrollment
- 97
- Locations
- 1
- Primary Endpoint
- The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma.
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.
Detailed Description
Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.
Investigators
George L. Spaeth MD
Director Glaucoma Research Center Wills Eye; Director Medical Research and Education Glaucoma Service Foundation Wills Eye; Esposito Research Professor, Thomas Jefferson University
Wills Eye
Eligibility Criteria
Inclusion Criteria
- •Caucasian or African American
- •Male or female with POAG, PACG, PXFG,
Exclusion Criteria
- •Other ophthamic co-morbidities
- •Other ethnic groups
- •Unable to understand and give informed consent
Outcomes
Primary Outcomes
The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma.
Time Frame: one blood draw