CTRI/2020/09/027527招募中未知
Efficacy of Vitamin C on AKI Outcomes in Critically Ill Cirrhotics With Multidrug-resistant Bacterial Infections- A Randomized Controlled Trial
试验速览
- 阶段
- 未知
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Critically ill cirrhotics with MDR infections
排除标准
- •1.Patients with age less than 18 years
- •2.Known severe cardiopulmonary disease (structural or valvular heart disease, coronary artery disease, COPD)
- •3.Patients in DIC with platelets < 20,000 and INR > 4 or active bleeding
- •4.Limitations of care (defined as refusal of cardiovascular and respiratory support modes) including do not intubate (DNI) status
- •5.Current hospitalization > 15 days for patients with nosocomial acquisition of MDR at time of randomization
- •6.Known allergy or contraindication to vitamin C (including previously or currently diagnosed primary hyperoxaluria and/or oxalate nephropathy, or known/suspected ethylene glycol ingestion,
- •7.Known glucose-6-phosphate dehydrogenase (G6PD) deficiency)
- •8.Use of vitamin C at a dose of > 1 gram daily within the 24 hours preceding first episode of qualifying organ dysfunction during a given ED or ICU admission
- •9.Patients with HCC (beyond Milan) or extrahepatic malignancies
- •10.Patients with HVOTO or EHPVO
- •11.Pregnancy or active breastfeeding
- •12.Current participation in another interventional research study
- •13.Active or history of kidney stone
- •14.History of chronic kidney disease or intrinsic kidney disease
- •15.Patients already on maintenance hemodialysis prior to presentation
- •16.Patients with refractory septic shock or hypoxemia (Pa02/Fio2 ratio <100)
- •17.Extremely moribund patients with an expected life expectancy of less than 24 hours
- •18.Failure to provide informed consent
- •19.Patients with retroviral infection
- •20.Patients with acute on chronic liver failure (APASL definition)
- •21.Patients with urinary tract infection
研究者
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