Neuropsychological Characterisation of Cognitive Deficits Involved in Reading Disability in Children With NF1

University Hospital, Toulouse6 sites in 1 country181 target enrollmentJune 2009

ConditionsNeurofibromatosis Type 1

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Neurofibromatosis Type 1
Sponsor: University Hospital, Toulouse
Enrollment: 181
Locations: 6
Primary Endpoint: Phonological deficits evaluated by the metaphonological capabilities including a subtraction test and phonemic Acronym test and memory capacity with phonological phonological memory test.
Status: Completed
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.

Detailed Description

To determine the phonological and visio -spatial performances at the NF1 children.

Registry

clinicaltrials.gov

Start Date

June 2009

End Date

April 2014

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University Hospital, Toulouse

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age included between 8 and 12 years
•Child presenting a type 1 neurofibromatosis according to 2 criteria in the following criteria list :
•At least 6 café au lait spots
•2 or more neurofibromas or 1 plexiform neurofibroma
•axillary or inguinal freckling
•1 optic nerf glioma
•2 or more Lisch nodules
•1 osseous lesion as sphenoid dysplasia or thinning of the long bone cortex with or without pseudoarthrosis
•1 A first degree relative (parent, sibling, or offspring) with NF1 by the above criteria
•Membership in a national insurance

Exclusion Criteria

•Mental retardation (QI T \< 70)
•Treated or untreated epilepsy
•Visual deficit (visual Acuteness \< 4/10
•Presence of a symptomatic optic glioma
•Presence of a brain tumor.

Outcomes

Primary Outcomes

Phonological deficits evaluated by the metaphonological capabilities including a subtraction test and phonemic Acronym test and memory capacity with phonological phonological memory test.

Time Frame: 24 hours

Evaluate whether there is a specificity of phonological deficits in children with NF1 compared with a population of children with the same age and same reading level, taking into account the intellectual level.

Secondary Outcomes

Visual-perceptual performance established from three tests: Test of Identical Forms (Thurstone), Judgment Test of orientation Lines (Benton) and global and partial deferral Tasks (S Valdois).(24 hours)