Maxi-Analgesic Study. A prospective, parallel group, double-blind comparison of the analgesic effect of a combination of paracetamol and ibuprofen, paracetamol alone or ibuprofen alone in patients with post-operative pain.

AFT Pharmaceuticals0 个研究点目标入组 120 人开始时间: 2006年7月10日最近更新: 2020年1月13日

试验速览

暂无简介。

•Undergoing oral surgery (including extraction of at least one lower 8th molar tooth under local or general anaesthetic).

•Consent:• Patient declinedStudy contra-indications:• Too young (< 16 years)• Other Non-steroidal anti-inflammatory drug (NSAID) (other than aspirin = 150mg mg/day) or opioid within 24 hours prior to operation• Treatment within 12 hours with other paracetamol or paracetamol containing medicines (e.g. cold treatments) • Pregnant or possibly pregnant• Breastfeeding• Neurological disorder relating to pain perception• History of drug addiction• Currently on another experimental agent• Weight < 50kg• Belief by the clinician that participation in the study may compromise the patient NSAID and/or paracetamol contra-indications:• Hypersensitive to aspirin or other NSAID• Hypersensitive to paracetamol• Severe known haemopoetic, renal* or hepatic disease• GI ulcer, severe asthma, allergy etc• Currently on ACE inhibitor, warfarin, steroid (other than dexamethasone intra-operatively)**, cyclosporin, tacrolimus, methotrexate• Severe local infection. Immunosuppressed.

发起方

AFT Pharmaceuticals