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Clinical Trials/NCT05111405
NCT05111405
Recruiting
Not Applicable

A Randomized Prospective Multicenter Study Comparing Suture Button Suspensionplasty (SBS) with Ligament Reconstruction and Tendon Interposition (LRTI)

Fraser Orthopaedic Research Society2 sites in 1 country138 target enrollmentJune 20, 2022
ConditionsArthritis

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Arthritis
Sponsor
Fraser Orthopaedic Research Society
Enrollment
138
Locations
2
Primary Endpoint
Visual Analog Scale- Pain
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

A multi-center, randomized control trial comparing the two standard of care surgical treatments for CMC arthritis ; trapezial excision with or without soft tissue interposition and /or ligament reconstruction (LRTI) versus the suture button suspension arthroplasty (SBS). Patient reported outcomes will be collected at 6 and 6 weeks, 3, 6, and 12 months.

Detailed Description

LRTI is a well established treatment of CMC arthritis with good results.However, comparable results have also been reported with SBS, with the latter procedure eliminating the need for flexor carpi radialis (FCR) harvest and interposition, resulting in potential shorter OR time and donor site morbidity. To date, there have been biomechanical studies comparing LRTI vs suture button suspension arthroplasty (SBS), and clinical studies comparing trapeziectomy alone vs SBS, but to the best of our knowledge, no random control studies comparing LRTI with SBS.The primary objective is to determine whether treatment with SBS results in improved overall pain relief compared to LRTI as measured by patient reported outcomes.Secondary outcome measures will be to determine if SBS results in shorter OR time and improved grip and pinch strength compared to LRTI, as well as have comparable return to work times and amount of radiographic shortening as shown on radiographs (metacarpal shortening has been felt to lead to decreased grip strength).

Registry
clinicaltrials.gov
Start Date
June 20, 2022
End Date
May 2026
Last Updated
last year
Study Type
Interventional
Study Design
Sequential
Sex
All

Investigators

Sponsor
Fraser Orthopaedic Research Society
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Age fifty years or older
  • Isolated carpometacarpal (trapeziometacarpal) osteoarthritis
  • Failure to respond to non-operative management
  • Willing and able to consent on their own behalf and follow the protocol and clinical visits as described
  • Able to read and understand English or have interpreter available

Exclusion Criteria

  • Previous surgery for CMC arthritis
  • Duration of symptoms for less than 6 months
  • Greater than or equal to 30 degrees of ipsilateral metacarpophalangeal (MCP) hyperextension
  • Scaphotrapeziotrapezoidal (stage 4 CMC) arthritis
  • Other significant ipsilateral wrist or hand pathology
  • A history of inflammatory arthropathy
  • A requirement for concomitant surgery for another condition
  • Any previous hand or wrist fracture
  • Likely problems, in the judgement of the investigators, with maintaining follow-up (i.e. patients with no fixed address, not mentally competent to give consent, intellectually challenged patients without adequate support, etc.)

Outcomes

Primary Outcomes

Visual Analog Scale- Pain

Time Frame: 12 Months

Participants overall assessment of their pain at maximal key pinch loading on a 10 cm visual analogue scale

Disabilities of the Arm, Shoulder and Hand Questionnaire

Time Frame: 12 Months

A 30 Item questionnaire that measures an individuals' ability to complete tasks, absorb forces and severity of symptoms. Lower scores will indicated better outcomes.Lower scores will indicate better outcomes.

Patient Related Wrist Evaluation Questionnaire

Time Frame: 12 Months

A 15 item questionnaire to measure wrist pain and disability pain in activities of daily living

Secondary Outcomes

  • Operative Time(Intraoperative)
  • Range of Motion(12 Months)
  • Strength(12 Months)
  • Work Productivity and Activity Impairment: Specific Health Problem Questionnaire(12 Months)

Study Sites (2)

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