NL-OMON50443RecruitingNot Applicable
Favorable and unfavorable effects of risk-reducing salpingo-oophorectomy (RRSO) in women at high genetic risk of ovarian cancer - HARMOny (Health After eaRly Menopause due to Oophorecomy)
Antoni van Leeuwenhoek Ziekenhuis0 sites750 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 750
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •Female patients
- •High genetic risk of ovarian cancer
- •Risk reducing salpingo-oophorectomy before the age of 46, or (for control
- •High genetic risk for ovarian cancer
- •Natural menopause after age of 50 years
- •No RRSO before 55 years of age
- •No treatment induced menopause before 50 years of age
Exclusion Criteria
- •For both groups:
- •History of gynecological cancer at time of RRSO
- •History of cancer at time of testing for BRCA-1 / BRCA-2
- •Ovariectomy for other reasons in patient history
- •Cystectomy in patients history
- •Metastatic disease
- •Other serious comorbidity, psychiatric disorders, which would interfere with a
- •clinic visit
- •Not enough understanding of the Dutch language
- •Non-bioresorbable cardiac stent
- •Younger age than 55 years
- •Premature Ovarian Insufficiency
Investigators
Similar Trials
Completed
Not Applicable
Impact of risk-reducing bilateral salpingo-oophorectomy on non-cancer outcomes in young high-risk women: A multicentre prospective studyWomen at risk of developing ovarian and/or breast cancer who have undergone Risk Reducing Bilateral Salpingo-Oophorectomy (RRBSO)Cancer - Ovarian and primary peritonealCancer - BreastReproductive Health and Childbirth - Menstruation and menopauseACTRN12615000082505Peter MacCallum Cancer Centre224
Completed
Not Applicable
Comparison of risk and patient-related benefit of treatment with etanercept in elderly patients with rheumatoid arthritisM06.99DRKS00012590Charité - Universitätsmedizin BerlinKlinik mS Rheumatologie und Klinische Immunologie85
Withdrawn
Phase 2
Comparison between ketamine and dexmedetomidine as adjuvants in Pectoral Nerves Regional Blocks for perioperative pain control for patients undergoing breast cancer surgeryACTRN12617000851369Amira Soliman90
Completed
Not Applicable
Clinical trial of different treatments in shoulder dislocatioCondition 1: Dislocation of shoulder joint. Condition 2: Dislocation of shoulder joint.Dislocation of shoulder jointContusion of shoulder and upper armIRCT201009264811N1Shahid Beheshti University of Medical Sciences150
Completed
Phase 2
Comparison of the efficacy and complications of sublingual versus vaginal misoprostol for induction of laborfor women in term pregnancyIRCT201402096541N3Shiraz University of Medical Sciences- Vice Chancellor for Research200