Evaluation of Elastic Properties of Ascending Aorta

Recruiting

• Conditions: Compliance, Magnetic Resonance Imaging, Biaxial Testing, Elastic Modulus

• Registration Number: NCT05252143
• Lead Sponsor: Centre Hospitalier La Chartreuse

Brief Summary

The aim of our study is to assess a correlation between local patient specific elastic modulus distribution of the ascending aorta from a biaxial tensile test and MRI measurements of the elastic properties of the aorta.

A total of 70 patients referred for ascending aorta (AA) replacement underwent a preoperative cardiac-MRI for the evaluation the elastic properties and ascending aorta tissue was collected for biaxial testing to obtain maximum elastic modulus

Detailed Description

Observational and prospective trial on medical data only. The patients are operated of planned aortic aneurysm without additional intervention.

The preoperative cardiac MRI are planned in standard of care.

Study Timeline

• Study Start: 2018-12-01
• Status Verified: 2022-02
• Primary Completion: 2022-02-14
• Study First Submitted: 2022-02-14
• Study First Submitted QC: 2022-02-14
• Last Update Submitted: 2022-02-14
• Study First Posted: 2022-02-23
• Last Update Posted: 2022-02-23
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• patient referred for ascending aorta aneurysm requiering replacement
• elective patient

Exclusion Criteria

• claustrophobia
• contraindication to performing cardiac MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
aortic compliance of ascending aorta (mm2/mmHg)	preoperative cardiac MRI performing between 1 month and 1 day before surgery	aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processsing

Secondary Outcome Measures

Name	Time	Method
maximum elastic modulus (MPa) of ascending aorta	biaxial testing performing between 1 and 6 hours after procedure	maximum elastic modulus is a local measurement of elastic properties which is obtained by biaxial testing

Trial Locations

Locations (1)

Dijon University Hospital; 🇫🇷 Dijon, France