Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults

Not Applicable

Completed

• Conditions: Older Adults (50-90 Years)
• Interventions: Device: Sham Stimulation; Device: brain stimulation

• Registration Number: NCT01840839
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects. Slow wave sleep (SWS), in particular, with its slow oscillating activity have shown to enhance declarative, hippocampus-dependent memory representations. This impact of sleep on memory performance can be additionally enhanced by exogeneous induction of transcranial slow oscillating stimulation (tSOS) within the frequency range of SWS in humans (0,7- 0,8 Hz) during sleep, as has been demonstrated in young, healthy subjects. If older adults that commonly experiencing cognitive decline, including long-term retention of declarative memory - benefit from transcranial slow oscillatory stimulation (tSOS) during sleep in the same way has not been studied so far. The primary goal of the study is therefore to investigate the impact of oscillating current stimulation (tSOS) during a daytime nap on declarative memory consolidation in older adults.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-04-18
• Study First Submitted QC: 2013-04-25
• Study First Posted: 2013-04-26
• Study Start: 2013-10
• Primary Completion: 2015-05
• Study Completion: 2015-08
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-29
• Last Update Posted: 2018-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• age: 50-90 years
• right handed
• inobtrusive neuropsychological examination

Exclusion Criteria

• untreated severe internal or psychiatric diseases
• epilepsy
• other severe neurological diseases eg., previous major stroke, brain tumour
• dementia
• contraindications to MRI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
no stimulation	Sham Stimulation	Sham stimulation during periods of SWS
0,75 Hz stimulation	brain stimulation	transcranial slow oscilliating stimulation (tSOS)during periods of SWS

Primary Outcome Measures

Name	Time	Method
Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS	4 weeks	Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.

Secondary Outcome Measures

Name	Time	Method
1. Amount of Slow wave Sleep	4 weeks	1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
2. sleep spindels	4 weeks	2.Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
3. EEG-correlates	4 weeks	3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
4. further memory systems	4 weeks	4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.

Trial Locations

Locations (1)

Charite CCM Neurologie Berlin; 🇩🇪 Berlin, Germany