Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Slow Wave Sleep in Older Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS
Study Overview
Brief Summary
The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects. Slow wave sleep (SWS), in particular, with its slow oscillating activity have shown to enhance declarative, hippocampus-dependent memory representations. This impact of sleep on memory performance can be additionally enhanced by exogeneous induction of transcranial slow oscillating stimulation (tSOS) within the frequency range of SWS in humans (0,7- 0,8 Hz) during sleep, as has been demonstrated in young, healthy subjects. If older adults that commonly experiencing cognitive decline, including long-term retention of declarative memory - benefit from transcranial slow oscillatory stimulation (tSOS) during sleep in the same way has not been studied so far. The primary goal of the study is therefore to investigate the impact of oscillating current stimulation (tSOS) during a daytime nap on declarative memory consolidation in older adults.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 50 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •age: 50-90 years
- •right handed
- •inobtrusive neuropsychological examination
Exclusion Criteria
- •untreated severe internal or psychiatric diseases
- •other severe neurological diseases eg., previous major stroke, brain tumour
- •contraindications to MRI
Arms & Interventions
0,75 Hz stimulation
transcranial slow oscilliating stimulation (tSOS)during periods of SWS
Intervention: brain stimulation (Device)
no stimulation
Sham stimulation during periods of SWS
Intervention: Sham Stimulation (Device)
Outcomes
Primary Outcomes
Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS
Time Frame: 4 weeks
Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
Secondary Outcomes
- 1. Amount of Slow wave Sleep(4 weeks)
- 2. sleep spindels(4 weeks)
- 3. EEG-correlates(4 weeks)
- 4. further memory systems(4 weeks)
Investigators
Agnes Flöel
Prof. Agnes Flöel, MD
Charite University, Berlin, Germany