Open-label, single-center, randomized and parallel-group study to compare the efficacy of olopatadine hydrochloride and dextromethorphan hydrobromide in prolonged and chronic cough
Phase 4
Completed
- Conditions
- Prolonged and chronic cough
- Registration Number
- JPRN-UMIN000001009
- Lead Sponsor
- Kyoto University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients with a history of hypersensitivity to olopatadine hydrochloride or dextromethorphan hydrobromide 2. Patients receiving monoamine oxidase inhibitor (MAOI) therapy and for 14 days after stopping MAOI therapy 3. Patients with a history of other chest disease 4. Patients taking angiotensin-converting enzyme inhibitors. 5. Patients during pregnancy or lactation 6. Inappropriate patients from the doctor's viewpoint
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Symptom scores and VAS score(at 0 and 2 weeks) Capsaicin cough sensitivity test(at 0 and 2weeks) Concentrations of substance P in sputum and plasma(at 0 and 2weeks)
- Secondary Outcome Measures
Name Time Method 1. Pulmonary function tests(at 0 and 2weeks) 2. Inflammatory biomarkers of induced sputum and serum(at 0 and 2weeks) 3. Exhaled nitric oxide concentration(at 0 and 2weeks) 4. Parameters of impulse oscillometry(at 0 and 2weeks) 5. safety