Integrative Analysis of Human Glioblastoma Multiforme
Recruiting
- Conditions
- GBM
- Interventions
- Other: Normal brain tissue
- Registration Number
- NCT03005132
- Lead Sponsor
- Shanghai 10th People's Hospital
- Brief Summary
Integrative analysis of GBM
- Detailed Description
The investigators will analyzed proteomes of paired normal brain tissues and GBM, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal brain tissue, primary GBM carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of GBM characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1000
Inclusion Criteria
- Age ≤ 75 years with histologically proven GBM
- No severe major organ dysfunction
- World Health Organization (WHO) performance status of 0 or 1
- No prior cancer chemotherapy
Exclusion Criteria
- Age ≥ 76
- Severe major organ dysfunction
- WHO performance status of >1
- Prior cancer chemotherapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Normal brain tissue Normal brain tissue Normal brain tissue from GBM patients Metastasis tissues Normal brain tissue Metastasis tissues from GBM patients GBM tissues Normal brain tissue GBM tissues from GBM patients
- Primary Outcome Measures
Name Time Method 5 years overall survival 5 years
- Secondary Outcome Measures
Name Time Method 5 years disease-free survival 5 years 10 years overall survival 10 years 10 years disease-free survival 10 years
Trial Locations
- Locations (1)
Shanghai Tenth People's Hospital
🇨🇳Shanghai, Shanghai, China