The effect of Memantine add on sertraline in improvement of patients with major depressive disorder
Phase 1
- Conditions
- Major depressive disorder, recurrent severe without psychotic features.Major depressive disorder, recurrent severe without psychotic featuresF33.2
- Registration Number
- IRCT20170606034348N4
- Lead Sponsor
- Babol University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
in this clinical trial the patients aged 20-60 years that were refered to Yahyanejad Clinic selected. patients depressive disorder according to the DSM 5 & hamilton -depression scale more than 22
Exclusion Criteria
1.prssence of another diagnose in axis /2. use of anti depressant medication before 1 month/3.the history of ECT during 2 months later /4.suicide ideation /homicidal ideation /5.substance or alcohal use or abuse (exceps nicotion)/6.presence of any life-threatening condition or disorder./7.pregnancy or lactation 8.age under 20 and over 60 years old
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of memantine on depression is measured using the Hamilton Depression Rating Scale at intervals before the onset of treatment and in the second week. Timepoint: the first visit & week 2. Method of measurement: the hamilton depression rating scale (HAM-D).
- Secondary Outcome Measures
Name Time Method Also, at the fourth and eighth week after the start of treatment, the response to treatment will be measured using the Hamilton Depression Rating Scale . Timepoint: Fourth and eighth weeks. Method of measurement: Hamilton Depression Scale.