Electroencephalogram (EEG) Triggered Functional Magnetic Resonance Imaging (fMRI) in Epilepsy Patients
Not Applicable
Completed
- Conditions
- Epilepsy
- Registration Number
- NCT02193932
- Lead Sponsor
- Baptist Health South Florida
- Brief Summary
A prospective exploratory study in patients with drug resistant epilepsy with a target comparison of long term outcome. NeuroScan software modules and a MagLink will be used to acquire EEG in combination with MRI/fMRI data. The MagLink system is used for obtaining integrated EEG and Event Related Potential (ERP) recordings while the subject is inside the MRI machine, without compromising the raw EEG data.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2
Inclusion Criteria
- Refractory epilepsy cases, referred by the service of Neurology. These are cases whose pathophysiology is resistant to treatment, including change in medication and or added medication.
- Patients will be included if they agree to sign an Institutional Review Board approved written consent.
Exclusion Criteria
- Patients with overt symptoms or signs of anxiety than cannot cooperate during the recording inside the scanner, unless consent is given for the procedure to be performed with sedation by the anesthesia department.
- Patients who meet the regular exclusion criteria for Magnetic Resonance Imaging (MRI) studies per the prescreening form reviewed with all patients prior to exams
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Number of participants with at least 40 interictal epileptic discharges during the fMRI 1 year
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie seizure suppression in drug-resistant epilepsy using EEG-triggered fMRI with MagLink?
How does EEG-triggered fMRI compare to standard-of-care neuroimaging in predicting long-term outcomes for focal epilepsy patients?
Which electrophysiological biomarkers correlate with treatment response in NCT02193932's integrated EEG-fMRI epilepsy study?
What adverse events are associated with MagLink-based EEG-fMRI in epilepsy patients, and how are they managed clinically?
How do ERP features from EEG-triggered fMRI inform personalized treatment strategies for drug-resistant epilepsy compared to PET or MEG?
Trial Locations
- Locations (1)
Baptist Hospital
🇺🇸Miami, Florida, United States
Baptist Hospital🇺🇸Miami, Florida, United States