Microneedling with Fluorouracil in Patients with Stable Vitiligo
Phase 3
Recruiting
- Conditions
- vitiligo.Vitiligo
- Registration Number
- IRCT20221105056407N2
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
No new lesions and no progression of existing lesions for at least 2 years
Exclusion Criteria
pregnancy
allergy to 5- Fluorouracil
Patients with infectious patches, vitiligo spots on the mucous membrane, Kubner's phenomenon, tendency to keloid or hypertrophic scars.
Coagulation disorders
Other uncontrolled systemic diseases
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Discoloration of vitiligo spots. Timepoint: Evaluation of lesions in both groups will continue every month until three months after the end of the interventions. Method of measurement: Discoloration of vitiligo patches will be graded as 1 (no response, milky white color still present, or erythematous color), 2 (opaque white color change), 3 (light brown color change), and 4 (normal skin color). Evaluation will also be done using the pigment score, which compares baseline vitiligo status and percent improvement as follows: 0, no response, <25% poor response, 25%–50% good response, 50%–75% Very good response, >75%, excellent response.
- Secondary Outcome Measures
Name Time Method Treatment complications. Timepoint: Evaluation of lesions in both groups will continue every month until three months after the end of the interventions. Method of measurement: Examination and history taking by the doctor.