Colloid Osmotic Pressure and Osmolality in Hyponatremia. Additional Diagnostic Aspects and Guide to Treatment
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Colloid osmotic pressure
研究概览
简要总结
Hyponatremia (serum sodium of less than 135 mmol/L)is a very common electrolyte disorder. The reasons for the disorder varies as well as if it is acute or chronic.
In this study we wish to follow changes in colloid osmotic pressure and osmolality during the initial treatment hours. We also wish to use mass balance for the calculation of body compartments and to detect fluid translocation between these.
详细描述
Patients with hyponatremia arriving att the intensive care unit are asked to participate in the study. The first blood samples are collected before initializing the treatment as well as measurements of body compartments with a bioimpedance analyzer. Collected blood samples are electrolytes (Sodium, Potassium and Chloride), colloid osmotic pressure, osmolality and hemoglobin. These samples are repeated at 4 and 8 hours after start of the study. Amount of infused fluid as well as electrolytes are recorded. Urine volume is measured and urine samples are analyzed for the loss of electrolytes.
Additional samples for guidance of treatment are collected every hour.
Hopefully the addition of colloid osmotic pressure, osmolality and mass balance can be beneficial in the diagnosis of the reason for the disorder as well as for the treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients treated for Hyponatremia at the intensive care unit.
排除标准
- •Circulatory instable patients in need of treatment for more than the hyponatremia.
研究组 & 干预措施
Hyponatremia
Patients treated for hyponatremia (<125 mmol/L Sodium) in the intensive care department.
干预措施: Sodium chloride (Drug)
结局指标
主要结局
Colloid osmotic pressure
时间窗: 8 hours
Measurement of colloid osmotic pressure
次要结局
- Body compartments(8 hours)
研究者
Joachim Zdolsek
MD, PhD, Assoc prof, consultant
University Hospital, Linkoeping