NCT02029261撤回不适用
Project 4: Molecular Mechanisms in Burn-induced Insulin Resistance in Humans
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Determination of gene expression profile and protein expression
研究概览
简要总结
The purpose of this study is to examine important and significant problems, that of insulin resistance and muscle wasting after burn injury.
详细描述
Burn injury induces insulin resistance and our investigators have previous shown the importance of insulin receptor substrate 1 (IRS-1)-mediated pathways. This project will establish the inhibitory effects of burn injury on IRS-1 mediated signaling in human skeletal muscle of burn patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Burn injury >=10% total body surface area involvement from any etiology that will require surgical treatment
- •Age 18 years or older
- •Admitted to the Massachusetts General Hospital within 30 days of burn injury
- •Patient or guardian who is capable of giving full informed consent
排除标准
- •Decision not to treat due to severity of injury
- •Presence of anoxic brain injury that is not expected to result in complete recovery
- •Existence of co-morbid conditions of malignancy currently under treatment, medical condition requiring glucocorticoid treatment, insulin dependent diabetes mellitus, morbid obesity defined as body mass index >= 40
结局指标
主要结局
Determination of gene expression profile and protein expression
时间窗: Time of burn injury up to 24 months postinjury
Determination of individual profiles and comparison with profiles from existing patients and healthy controls
次要结局
- Presence of clinical complications(From hospital admission to discharge)
- Hospital discharge status(From hospital admission to discharge)
- Correlation between protein data and in vivo physiologic measurement data(Hospitalization)
- Nutritional status at discharge(At hospital discharge)
- Intensive care unit (ICU) days(From hospital admission to discharge)
研究者
Ronald G. Tompkins
Chief, Burns Division
Massachusetts General Hospital
研究点 (1)
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