Does intravenous lidocaine speed up gut recovery after large bowel surgery?

Not Applicable

Completed

• Conditions: Colorectal resection for colorectal cancer or diverticular disease.; Digestive System

• Registration Number: ISRCTN52352431
• Lead Sponsor: ACCORD

Brief Summary

2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35090535/ (added 31/01/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-06-13
• Study Completion: 2023-07-31
• Last Update Posted: 2 August 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 562

Inclusion Criteria

Scheduled for elective colorectal resection for colorectal cancer or diverticular disease at participating UK colorectal surgery units. Right hemicolectomy, extended right hemicolectomy, left colectomy, sigmoid colectomy, subtotal colectomy with ileosigmoid or ileorectal anastomosis and high anterior resection are eligible.

Exclusion Criteria

1. Planned epidural anaesthesia
2. Planned regional or local infiltration of lidocaine at the same time as lidocaine infusion
3. Pregnancy
4. Breastfeeding
5. Patients lacking capacity to give informed consent
6. Known or suspected allergy to lidocaine or amide-type local anaesthetics
7. Current complete heart block
8. Current severe liver dysfunction (Child’s A or greater)
9. Current renal failure (eGFR <30)
10. Participation in the active intervention phase of another therapeutic clinical trial (or other interventional trial) unless a co-enrolment agreement is in place
11. Patients having surgery for indications other than colorectal cancer/diverticular disease
12. Rectal cancer below the peritoneal reflection in which total mesorectal excision is anticipated
13. Rectal cancer patients who have received any neoadjuvant radiotherapy
14. Preoperative surgical plan to form any new stoma during the primary procedure

Study & Design

• Study Type: Interventional
• Study Design: Not specified