Effects of hydro-alcoholic artichoke leaf extract supplementation on metabolic and antioxidant status in patients with metabolic syndrome with regard to genetic polymorphism

Not Applicable

• Conditions: metabolic syndrom.; Metabolic disorder, unspecified

• Registration Number: IRCT201409033320N9
• Lead Sponsor: Vice Chancellor for Research (VCR) of Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

willingness and ability to collaborate on project ; aged between 20-60 years (both sexes); affected by metabolic syndrome: having at least 3 of 5 criteria according to international definition: waist circumference >91 cm in women and >89cm in men, serum glucose =100 mg/dl, serum triglyceride =150 mg/dl, HDL-C >40 mg/dl in men and >50 mg/dl in women, systolic blood pressure = 130 mmHg and/or diastolic blood pressure = 85 mmHg
Exclusion criteria: Smoking ; Consumption of fish oil supplement or other antioxidant supplements currently or within 3 months before intervention; Consumption of lipid or blood pressure lowering drugs, corticosteroids currently or within 3 months before intervention; affected by cardiovascular disease, renal failure, diabetes mellitus, liver dysfunction, cancer; affected by Infectious or inflammatory disease or recent surgery; affected by malabsorption, such as sprue and Crohn's disease; affected by hypothyroidism or hyperthyroidism; having gallstones and biliary tract obstruction; having a weight loss diet at the time of the study; pregnancy or lactation; history of allergy to artichoke family plants and their products; menopause

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fasting blood suger and Serum Lipid profile. Timepoint: at the beginning and end of intervention. Method of measurement: Fasting blood suger by enzymatic method and triglycerid, total cholestrol and HDL-C by espectrophotometry method and LDL-C by Friedewald Formula.;Serum levels of total antioxidants capacity and Malondialdehyde. Timepoint: at the beginning and end of intervention. Method of measurement: TAC: Espectrophotometry by Rabdox enzymatic kit; MDA: Reaction with thiobarbituric acid by fluorimetry method.;Serum level of CETP. Timepoint: at the beginning and end of intervention. Method of measurement: By Laboratory ELISA Kits.