CTRI/2018/01/011373
Not yet recruiting
未知
A randomized controlled trial comparing the efficacy and safety profile of oral versus subcutaneous route of methotrexate administration in moderate to severe psoriasis - METOS
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Health Condition 1: null- Psoriasis Vulgaris
- Sponsor
- Postgraduate Institute of Medical Education and Research
- Status
- Not yet recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\)Patients aged more than 18 years with clinical diagnosis of plaque psoriasis
- •2\)Patients with body surface area involvement \> 10 %, PASI \>10,
Exclusion Criteria
- •1\)Hemoglobin \< 8 gm/dl ,Total leukocyte count \< 3500/ mm3, Platelet count \< 100,000/mm3
- •2\)Elevation of hepatic enzymes (alanine aminotransferase \[ALT], aspartate aminotransferase \[AST], or γ glutamyl transferase \[GGT]) to more than twice the upper limit of normal.
- •3\)Hepatitis, active or recurrent, cirrhosis or excessive current alcohol intake .
- •4\)Use of other hepatotoxic drugs by the patient
- •5\)Positive hepatitis B, hepatitis C or HIV serology
- •6\)Pulmonary or extra\-pulmonary active tuberculosis
- •7\)Deranged renal function test.
- •8\)Pregnancy or lactation or if patient is planning to conceive during the treatment period.
- •9\)Patient on other immunosuppressive drugs
- •10\)Recent live vaccination
Outcomes
Primary Outcomes
Not specified
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