NCT04240444已完成不适用
A Prospective, Multicenter, Randomized Controlled Clinical Trial to Assess the Safety and Efficacy of SeQuent® SCB Balloon in the Treatment of Patients With Coronary Arteries In-stent Restenosis Compared SeQuent® Please Neo
B. Braun Medical International Trading Company Ltd.16 个研究点 分布在 1 个国家目标入组 260 人开始时间: 2020年10月10日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 260
- 试验地点
- 16
- 主要终点
- In-segment late loss
研究概览
简要总结
This is a prospective, multicenter, randomized controlled clinical trial, which plans to enroll 260 subjects.
详细描述
This is a prospective, multicenter, randomized (1:1) controlled clinical trial, which plans to enroll 260 subjects. The aim of study is to assess the safety and efficacy of SeQuent® SCB in the treatment of in-stent restenosis in coronary arteries.
All eligible subjects with ISR lesion in coronary will be randomly assigned to receive SeQuent® SCB (study group) or receive SeQuent® Please Neo (control group) balloon treatment. All subjects will be scheduled to clinical follow up at 30 days, 6 months, 9 months and 12 months after index procedure and will be scheduled to receive the angiography at 9 months after index procedure. The primary endpoint was segment late luminal loss at 9 months after index procedure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •General criteria
- •Patient ≥18 years of age.
- •Stable angina pectoris or unstable angina pectoris (acute coronary syndrome), prior myocardial infarction or proven asymptomatic myocardial ischemia.
- •Patients are eligible for any type of coronary revascularization.
- •Patients agree to receive angiography follow-up at 9 months after index procedure.
- •Patients agree to receive clinical follow-up at 30 days, 6months, 9 months and 1years after index procedure.
- •Patients are able to understand the purpose of the study and will comply with the study protocol. The patient is willing to sign informed consent form and understand the risks and benefits described in the informed consent form.
- •lesion related
- •Up to 2 ISR lesions which found by angiography (diameter stenosis ≥70% or ≥ 50% with evidence of ischemia) or functional examination (e.g. FFR<0.8 IVUS<4mm2) will be treated, target segment includes news lesions within 5mm of the stent margin.
- •Up to 2 drug coated balloons (SeQuent® Please Neo or SeQuent® SCB) will be used in the study, with 1 drug coated balloon per lesion.
- •ISR (including bare stents, inert and active drug eluting stents) : Mehran type I, II and III stenosis; The reference vessel diameter of target lesions ranges from 2.5mm to 4.0mm (visual), and the length of each lesion are≤ 34mm (visual).
- •Other de novo lesions needing treatment must be >10mm away from the target lesion.
排除标准
- •General criteria
- •Patients with myocardial infarction within 1 week before index procedure.
- •Patients with takayasu arteritis.
- •Patients with severe renal failure, whose Creatinine >2.0 mg/dL (177 mol/L).
- •Hb before procedure <10 g/dL.
- •Patients with Coagulation disorder, platelet count <100,000/mm
- •Patients with cardiogenic shock.
- •Patients with diseases who require cytostatic or radiotherapy.
- •Patients who are known to be allergic or contraindicated to aspirin, heparin, clopidogrel, rapamycin, ticagrelor, tirofiban, paclitaxel, or iopromide , or who are allergic to contrast agents and cannot be medically prevented, or who are on cilostazol anticoagulants.
- •Patients with bleeding conditions, or with conditions that increase the risk of bleeding, such as gastrointestinal ulcers, which may be restricted or prohibited from anticoagulant therapy or the use of anticoagulant drugs.
- •Gestational women who were pregnant before receiving treatment with the study device or who planned to be pregnant during the study , and did not use effective contraception until (including) follow-up at 12 months postoperatively; Female patients during lactation.
- •Patients with a life expectancy less than 1 year.
- •Patients who are participating in any other clinical trial.
- •Investigator considered the patients ineligible due to any reasons.
- •lesion related
- •There are more than 3 lesions to be treated (including non-target lesions to be treated), and there are more than 2 lesions to be treated in each coronary artery.
- •There will be more than 5 stents implanted in coronary artery after intervention (including previous and current PCI).
- •After pre-dilatation of target lesion, there will be residual stenosis of target lesion >30% or TIMI blood flow < grade 3, and/ dissections NHLBI grade C,D,E,F.
- •The ISR lesion has been treated in past 6 months.
- •The target lesion is tortuous, severely calcified, angular, and the DCB is expected to be impassable.
- •Target lesion contains thrombosis.
- •Target or non-target lesion(s) located in left main.
- •Patients with previous CABG.
- •Patients with lesions requiring intervention treatment in 3 vessels
结局指标
主要结局
In-segment late loss
时间窗: at 9 months after index procedure
In-segment late loss(LLL) is defined as the difference between the MLD immediately after the procedure and the MLD at 9-month follow-up angiography after index procedure. MLDs are measured by QCA.
次要结局
- Binary restenosis rate of target lesion(9 months after index procedure)
- The success rate of intervention treatment(1-3 days)
- PoCE(30 days, 6 months, 9 moths, 12 months after index procedure)
- Target lesion failure (TLF) rate(30 days, 6 months, 9 moths, 12 months after index procedure)
- ARC-defined stent thrombosis(30 days, 6 months, 9 moths, 12 months after index procedure)
研究者
研究点 (16)
Loading locations...
相似试验
终止
3 期
Prospective, Multicenter, Randomized Controlled Study to Evaluate the Effect of INTERCEED™Subjects Scheduled to Undergo Laparoscopic Radical Resection of Rectal Carcinoma With Preventive IleostomyNCT03462563Ethicon, Inc.175
招募中
不适用
Clinical Trial of the MiniStim PNS for Knee Pain- "FLEX" StudyChronic Knee PainNCT04580732MiniStim LLC350
已完成
不适用
Lateral Branch Cooled Radiofrequency Denervation vs. Conservative Therapy for Sacroiliac Joint PainSacroiliac Joint PainNCT03601949Avanos Medical210
尚未招募
不适用
The Clinical Efficacy of Drug Sensitive Neoadjuvant Chemotherapy Based on Organoid Versus Traditional Neoadjuvant Chemotherapy in Advanced Rectal CancerNeoadjuvant TherapyNCT05352165Shanghai Minimally Invasive Surgery Center192
撤回
不适用
Prospective Randomized International Study on the Reactivation of Burn InjuriesBurnsSkin Graft (Allograft)(Autograft) FailureNCT04951934Emoled