Comparative evaluation of Nebulized Lignocaine with that of Nebulized Dexmedetomidine in blunting haemodynamic response to intubation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To find out the changes in hemodynamic variables (in terms of 20% rise from baseline values) in two groups of patients belonging to both the genders undergoing elective surgeries under general anaesthesia with endotracheal intubation.
研究概览
简要总结
This study is a Randomized,double blinded , parallel group trail comparing the efficacy nebulized lignocaine with that of nebulized dexmedetomidine in blunting hemodynamic response to laryngoscopy and intubation in patients undergoing elective surgeries under general anaesthesia. This trial will be conducted in 60 patients with ASA grades 1& 2 in india.The primary outcome is to find out changes in hemodynamic variables in two groups of patients belonging to both the genders undergoing elective surgeries under general anaesthesia with endo tracheal intubation .Secondarily,to study any adverse effects of the drug such as bradycardia,hypotension,and postoperative sedation and sore throat.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients aged 18 to 60 years for both sexes belonging to ASA class 1,2 posted for elective surgeries under GA.
排除标准
- •1.History of allergies to local anaesthetic agents or to the study drug.
- •2.Refusal by patient to participate in study
- •Patients of ASA class 3 and
- •4.Patients with anticipated difficult airway.
- •5.Baseline heart rate <60 bpm and Blood pressure <90/50(65) mmHg 6.Patients weighing < 40 kg.
结局指标
主要结局
To find out the changes in hemodynamic variables (in terms of 20% rise from baseline values) in two groups of patients belonging to both the genders undergoing elective surgeries under general anaesthesia with endotracheal intubation.
时间窗: upto 15 minutes post intubation
次要结局
- To study any adverse effects of the drug such as bradycardia, hypotenstion and post operative sedation and sore throat.(upto 24 hrs postoperatively)