Nebulized Lignocaine versus Nebulized Dexmedetomidine in blunting stressor response to intubation

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2022/10/046812
• Lead Sponsor: PASUPALA SUBBA KAVYA SREE

Brief Summary

This study is a Randomized,double  blinded , parallel   group  trail comparing the efficacy  nebulized lignocaine with that of nebulized dexmedetomidine in blunting hemodynamic response to laryngoscopy  and  intubation  in patients undergoing elective surgeries under general anaesthesia. This trial will be conducted in 60 patients with ASA grades 1& 2 in india.The primary outcome is  to find out changes in hemodynamic variables in two groups of patients belonging to both the genders undergoing elective surgeries under general anaesthesia with endo tracheal intubation .Secondarily,to study any adverse effects of the drug such as bradycardia,hypotension,and postoperative sedation and sore throat.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-10-20
• Study Start: 2022-10-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1.Patients aged 18 to 60 years for both sexes belonging to ASA class 1,2 posted for elective surgeries under GA.

Exclusion Criteria

• 1.History of allergies to local anaesthetic agents or to the study drug.
• 2.Refusal by patient to participate in study 3.
• Patients of ASA class 3 and 4.
• 4.Patients with anticipated difficult airway.
• 5.Baseline heart rate <60 bpm and Blood pressure <90/50(65) mmHg 6.Patients weighing < 40 kg.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To find out the changes in hemodynamic variables (in terms of 20% rise from baseline values) in two groups of patients belonging to both the genders undergoing elective surgeries under general anaesthesia with endotracheal intubation.	upto 15 minutes post intubation

Secondary Outcome Measures

Name	Time	Method
To study any adverse effects of the drug such as bradycardia, hypotenstion and post operative sedation and sore throat.	upto 24 hrs postoperatively

Trial Locations

Locations (1)

Institute of medical sciences and SUM hospital; 🇮🇳 Khordha, ORISSA, India

Institute of medical sciences and SUM hospital

🇮🇳Khordha, ORISSA, India

Dr Pasupala Subba kavya sree

Principal investigator

7386361350

lovelykavya85@gmail.com