The Mechanism Study of Diabetic Pancreatic Amyloid Deposition on Cognitive
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Complete PET imaging
研究概览
简要总结
Alzheimer's disease (AD) is closely related to diabetes (DM). DM will aggravate the progression of AD, but the specific mechanism has not yet been clarified. Previous study found that a key pathological feature of the pancreas in patients with DM is islet amyloid polypeptide, and there is also islet amyloid polypeptide in the brain. Therefore, DM may cause cytotoxicity through the interaction between pancreatic amyloid and brain Aβ protein and further aggravate AD progress. In this study, starting with DM and AD pathological biomarkers, the amyloid PET target molecular probe 18F-AV45 will be used to monitor the dynamic changes of amyloid protein in the brain and pancreas during the development of AD. The completion of this study will provide a new view for understanding the mechanism of DM on AD cognitive dysfunction and effectively preventing and treating these two diseases.
详细描述
This is a single-center, prospective, and observational study, which mainly focuses on the interaction between pancreatic amyloid and brain Aβ protein and further aggravates AD progress in China. PET imaging will be used on subjects. Previously collected patient data may also be enrolled in this study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-disease controls:
- •Age between 60 and 80 years old; gender is not limited.
- •The investigators have normal cognition and negative Aβ imaging through the test.
- •Informed consent must be signed in writing by the subjects or their legal guardians and caregivers.
- •Blood routine: white blood cell count (WBC) 4~10×109/L; platelet (PLT) 100~300×109/L; hemoglobin (HB) 120~160 g/L; renal function: serum creatinine less than or equal to Upper limit of normal range; liver function: bilirubin, AST (SGOT)/ALT (SGPT) less than or equal to the upper limit of normal range; electrocardiogram: no significant abnormality.
- •Willingness and ability to cooperate with all projects of this research.
- •AD patients/DM patients:
- •Age between 60 and 80 years old; gender is not limited.
- •The diagnosis of AD was based on the 2011 National Association on Aging and Alzheimer's Disease (NIA-AA) diagnostic criteria for possible AD dementia. The diagnostic criteria for diabetes were based on the 1999 World Health Organization (WHO) diagnostic criteria for diabetes.
- •Brain MRI supports the diagnosis of AD, and there is no evidence of other neurological diseases.
- •No neurological disease, major chronic disease, malignant tumor or acute infectious disease has been confirmed by the investigator.
- •An informed consent form must be signed in writing by the subjects or their legal guardians and caregivers.
- •Blood routine: white blood cell count (WBC) 4~10×109/L; platelet (PLT) 100~300×109/L; hemoglobin (HB) 120~160 g/L; renal function: serum creatinine less than or equal to Upper limit of normal range; function: bilirubin, AST (SGOT)/ALT (SGPT) less than or equal to the upper limit of normal range; electrocardiogram: no significant abnormality.
- •Willingness and ability to cooperate with all projects of this research.
排除标准
- •Subjects meeting any of the following criteria will be excluded from the study:
- •Suffering from other serious neurological diseases, or gastrointestinal, cardiovascular, liver, kidney, blood system, tumor endocrine, respiratory system, immune deficiency and other serious diseases.
- •Candidate subjects have contraindications to PET/CT scanning. Those who cannot accept repeated intravenous injections; those who may be allergic to drugs and their components (including a history of severe allergy or allergic reactions, especially those who are allergic to the tested drugs); phobia of tightness.
- •In the past year, in addition to participating in the expected radiation exposure of this clinical study, have participated in other research programs or clinical care, resulting in radiation exposure exceeding the effective dose of 50 mSv.
- •Drug or alcohol abuse for at least 1 month.
- •The venous condition is poor and cannot tolerate repeated venipuncture.
- •The candidate subject has received major surgery within the past 3 months; received experimental drug or device treatment (with unclear effect or safety) within 1 month
- •The candidate subjects have any clinical conditions that the host of this study believes that this preparation may cause or have potential harm.
结局指标
主要结局
Complete PET imaging
时间窗: 50mins from time of injection
Assessment of PET/CT imaging to detect abeta in patients with AD and DM
次要结局
未报告次要终点