A Randomized, Open-Label, Two Arm Trial to Compare the Safety and Antiviral Efficacy of GW433908/Ritonavir QD to Nelfinavir BID When Used in Combination With Abacavir and Lamivudine for 48 Weeks in Antiretroviral Therapy Naive HIV-1 Infected Subjects
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 624
- 试验地点
- 73
研究概览
简要总结
The purpose of this study is to compare virus response to GW433908/ritonavir (RTV) to viral response to nelfinavir (NFV) when used with abacavir (ABC)/lamivudine (3TC) in patients that have not taken antiretroviral (ART) drugs.
详细描述
Patients are randomized to 1 of 2 treatment arms. One arm is treated with GW433908/RTV plus ABC and 3TC. The other is treated with NFV plus ABC and 3TC. Each group is treated for 48 weeks. The following are compared in the 2 arms: 1) magnitude and durability of antiviral response; 2) safety, tolerance, and antiviral response after 24 and 48 weeks of therapy; 3) time to treatment failure; 4) immunologic response; 5) occurrence of events related to metabolic abnormalities; and 6) development of viral resistance in a subset of patients following treatment. Also studied are: 1) steady-state plasma drug trough concentrations; 2) demographic, virologic, immunologic, pharmacologic, and adherence factors that may be associated with treatment outcome; 3) patient adherence to the drug regimens; 4) study medication utilization; and 5) resource utilization.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 13 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients may be eligible for this study if they:
- •Are at least 13 years old (consent of parent or guardian needed if under 18).
- •Agree to use a proven barrier method of birth control (e.g., spermicide plus condom) during the study period (hormonal birth control will not be accepted), if able to have children.
- •Have received less than 4 weeks treatment with any nucleoside reverse transcriptase inhibitor (NRTI) and have never received any nonnucleoside reverse transcriptase inhibitor (NNRTI) or protease inhibitor (PI). Mothers who have previously received 1 dose of the NNRTI nevirapine during pregnancy for prevention of mother-to-child HIV transmission are permitted to enter the study.
- •Have a viral load (amount of HIV in the blood) of 1,000 copies/ml or more.
排除标准
- •Patients will not be eligible for this study if they:
- •Abuse drugs or alcohol in a way that would interfere with study requirements. Patients who are stable on methadone will be considered for the study.
- •Have an active/acute CDC Category C event.
- •Are unable to absorb or take medicines by mouth.
- •Are pregnant or breast-feeding.
- •Have a serious medical condition (such as diabetes, heart problem, hepatitis) that might affect the safety of the patient.
- •Have had pancreatitis or hepatitis within the last 6 months.
- •Have been treated with radiation or chemotherapy within 28 days before the study drug will be taken, or will have the need for these during the study.
- •Have taken drugs that affect the immune system (such as corticosteroids, interleukins, interferons) or that have anti-HIV activity (such as hydroxyurea or foscarnet) within 28 days before the study drug will be taken.
- •Have received an HIV vaccine within 3 months before the study drug will be taken.
- •Have received certain other drugs within 28 days before the study drug will be taken, or think that they will be needed during the study.
- •Have received experimental treatments.
- •Have allergies which might interfere with the study, in the opinion of the doctor.