NCT03001271Unknown早期 1 期
Acute Effect of Agiotensin-(1-7) on Bood Pressure and Heart Rate in Healthy and Hypertensive Subjects
Instituto de Cardiologia do Rio Grande do Sul0 个研究点目标入组 32 人开始时间: 2014年1月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 发起方
- 入组人数
- 32
- 主要终点
- Absence of adverse effects after Ang-(1-7) acute administration
研究概览
简要总结
In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II. The aim is to evaluate the effect of Ang-(1-7) acute administration on systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in healthy and hypertensive subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •arterial pressure <140/90 mmHg
- •body mass index (BMI) between 18,5 and 29 Kg/m2
- •Hypertensive Group Inclusion Criteria:
- •anti-hypertensive drug treatment
- •ambulatory blood pressure monitoring (ABMP) >130/85 mmHg
- •body mass index between 18,5 and 29 Kg/m2
- •Healthy Group
排除标准
- •drug treatment
- •recent surgeries
- •pregnancy
- •previous cardiovascular events
- •high performance athletes
- •dislipidemia
- •renal injury
- •obesity (BMI above 30 kg/m2)
- •alcoholism
- •Hypertensive Group Exclusion Criteria:
- •recent surgeries
- •pregnancy
- •beta-blockers drug treatment
- •previous cardiovascular events
- •high performance athletes
- •dislipidemia
- •renal injury
- •obesity (BMI above 30 kg/m2)
- •alcoholism
研究组 & 干预措施
Healthy Subjects
Experimental
Placebo and Angiotensin-(1-7) acute infusion
干预措施: Angiotensin 1-7 (Drug)
Healthy Subjects
Experimental
Placebo and Angiotensin-(1-7) acute infusion
干预措施: Placebo (Other)
Hypertensive Subjects
Experimental
Placebo and Angiotensin-(1-7) acute infusion
干预措施: Angiotensin 1-7 (Drug)
Hypertensive Subjects
Experimental
Placebo and Angiotensin-(1-7) acute infusion
干预措施: Placebo (Other)
结局指标
主要结局
Absence of adverse effects after Ang-(1-7) acute administration
时间窗: Along 25 hours
次要结局
- Ang-(1-7) effects on Blood Pressure Variability(Along 1 hours after Ang-(1-7) acute administration)
- Heart Rate Changes after Ang-(1-7) administration(Recording along 24 hours)
- Blood Pressure Changes after Ang-(1-7) administration(Recording along 24 hours)
- Ang-(1-7) effects on Heart Rate Variability(Along 1 hours after Ang-(1-7) acute administration)
研究者
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