Effects of Carnosine Supplementation in Form of Capsules and Functional Food on Cardiovascular Function
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Microvascular endothelial function
Study Overview
Brief Summary
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high concentrations in the brain, heart, and gastrointestinal tissues of humans. Although its physiological role has not been completely understood yet, carnosine is a non-enzymatic free-radical scavenger and a natural antioxidant and has anti-inflammatory and neuroprotective properties.
The hypothesis of this research is that the consumption of carnosine supplements in the form of capsules, as well as chicken meat enriched with carnosine (functional food) has a beneficial effect on vascular reactivity measured in different vascular basins, and the lipid profile with a positive effect on the reduction of oxidative stress and inflammatory response in healthy sedentary people. subjects and active athletes measured in different vascular basins.
The main goal of this study is to investigate the influence of carnosine supplement consumption (in the form of capsules and functional food) on vascular and endothelial function in a population of healthy young subjects and active athletes.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 39 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •young healthy sedentary individuals - did not perform regular physical activities for at least 12 months before conducting the study
- •young healthy active athletes - have a minimum of 5 training sessions per week (mainly endurance training) for at least 12 months prior to conducting the study
Exclusion Criteria
- •hypertension
- •coronary disease
- •hyperlipidemia
- •kidney damage
- •cerebrovascular and peripheral artery diseases
- •and any other disease that could have an impact on vascular and endothelial function
Arms & Interventions
Carnosine
Intake of carnosine supplement in form of capsules or functionally enriched chicken meet for three weeks
Intervention: Carnosine supplementation (Dietary Supplement)
Control
Intake of placebo capsules or regular chicken meet for three weeks
Intervention: Controls (Dietary Supplement)
Outcomes
Primary Outcomes
Microvascular endothelial function
Time Frame: 3 weeks
Cutaneous microvascular blood flow will be measured by Laser Doppler Flowmetry in response to vascular occlusion (post occlusive reactive hyperaemia - PORH), in response to iontophoresis of acetylcholine (ACh) and local thermal hyperemia (LTH).
Macrovascular endothelial function
Time Frame: 3 weeks
Measurement of flow mediated dilation (FMD) of brachial artery using ultrasound.
Cerebrovascular reactivity
Time Frame: 3 weeks
Measurement of cerebrovascular blood flow using transcranial color Doppler (TCD).
Secondary Outcomes
- Oxidative stress status(3 weeks)
- Systemic hemodynamics(3 weeks)
- Lipid profile(3 weeks)
- Serum Pro- and Anti-Inflammatory Cytokines, Chemokines, Growth Factors and Soluble Cell Adhesion Molecules Protein Concentration(3 weeks)
- Body composition(3 weeks)
- Body fluid status(3 weeks)
Investigators
Ines Drenjancevic
Principal investigator
Josip Juraj Strossmayer University of Osijek